Recurrence of depressive episode at one year · bipolar disorder
Lamotrigine showed no clear difference in recurrence of depressive episode at one year compared with lithium (moderate certainty).
1 finding from 1 review
Health status and quality of life · bipolar disorder
1 finding from 1 review
Total severity score from depression and mania symptom scores, such as HDRS and the YMRS · bipolar disorder
1 finding from 1 review
Recurrence of any episodes at one year (Montgomery‐Asberg Depression Rating Scale (MADRS) total score ≥15 for depressive episode; Hamilton Depression Rating Scale (HDRS) total score ≥14 for depressive episode) · bipolar disorder
Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with placebo (low certainty).
1 finding from 1 review
Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder
Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).
1 finding from 1 review
Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder
1 finding from 1 review
no estimate extracted
1 study · 1 participants
GRADE not reported
Treatment withdrawal · bipolar disorder
It is very uncertain whether lamotrigine changes withdrawal from treatment due to any reason, up to 12 weeks after… compared with placebo (very low certainty).
1 finding from 1 review
Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder
Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).
1 finding from 1 review
Any reported adverse effects up to 12 weeks after starting treatment (short term) · bipolar disorder
It is very uncertain whether lamotrigine changes any reported adverse effects up to 12 weeks after starting treatment… compared with placebo (very low certainty).
1 finding from 1 review
Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder
Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).
1 finding from 1 review
Seizure freedom · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes proportion with seizure freedom compared with phenobarbital (very low certainty).
1 finding from 1 review
Proportion with adverse events · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes proportion with adverse events compared with phenobarbital (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · patients with AD and epileptic seizures
It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).
1 finding from 1 review
Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in cognition · patients with AD and epileptic seizures
1 finding from 1 review
Change in neuropsychiatric symptoms · patients with AD and epileptic seizures
1 finding from 1 review
Improvement in quality of life · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Activity limitations · people with postpolio syndrome
1 finding from 1 review
Adverse events · people with postpolio syndrome
1 finding from 1 review
50% or greater reduction in seizure frequency · people with drug‐resistant generalised tonic‐clonic seizures
Add‐on lamotrigine may leads to higher 50% or greater reduction in seizure frequency compared with placebo (low certainty).
1 finding from 1 review