Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 280 findings · 13 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 127 · 45.4%GRADE not reported 3 · 1.1%Very low 85 · 30.4%Low 46 · 16.4%Moderate 19 · 6.8%High 0 · 0%

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Compliance or adherence to the trial intervention (including satisfaction): use of intervention at least once · adults and children with hemophilia

Summary of findings ‐ DVD plus information booklet showed no clear difference in compliance or adherence to the trial intervention (including… compared with information booklet alone (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Adherence to inhaled therapies cMPR · children, adolescents or adults with CF

Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review