Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

159 questions · 192 findings · 40 reviews · Tobacco Addiction

No studies found 8 · 4.2%GRADE not reported 1 · 0.5%Very low 56 · 29.2%Low 70 · 36.5%Moderate 43 · 22.4%High 14 · 7.3%

Pharmacological interventions vs placebo

Smoking cessation · young people

It is very uncertain whether pharmacological interventions changes bupropion vs placebo Smoking cessation compared with placebo (very low certainty).

3 findings from 1 review

Pharmacological interventions vs placebo

Adverse events (control ‐ placebo) · young people
3 findings from 1 review

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after counselling (counselling) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions showed no clear difference in tobacco abstinence after counselling (counselling) compared with placebo or usual care (low certainty).

1 finding from 1 review

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after pharmacotherapy (pharmacotherapy) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions may leads to higher tobacco abstinence after pharmacotherapy (pharmacotherapy) compared with placebo or usual care (low certainty).

1 finding from 1 review

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after combined counselling and pharmacotherapy (combined) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions may leads to higher tobacco abstinence after combined counselling and pharmacotherapy… compared with placebo or usual care (low certainty).

1 finding from 1 review

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (6 to 9 months) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (6 to 9 months) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (12 months+) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (12 months+) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Community pharmacy personnel interventions vs standard care or less intensive support

Smoking cessation · people who smoke who were motivated to change their smoking behavior

Community pharmacy personnel interventions may leads to higher smoking cessation compared with standard care or less intensive support (low certainty).

1 finding from 1 review

Intervention not reported

Face‐to‐face behavioral intervention vs minimal or no support (Measured 3 to 6 months with CO‐validated prolonged and continuous abstinence, and self‐reported abstinence) · people who use waterpipe

The intervention may leads to higher face‐to‐face behavioral intervention vs minimal or no support… (low certainty).

1 finding from 1 review

Intervention not reported

Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe

The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).

1 finding from 1 review

Intervention not reported

E‐health interventions · people who use waterpipe

It is very uncertain whether the intervention changes E‐health interventions (very low certainty).

1 finding from 1 review

Intervention not reported

Comparisons between Internet interventions (programmes): tailored/interactive versus not tailored/interactive Self‐report or bio‐verified smoking cessation · adults who want to stop smoking

The intervention showed no clear difference in comparisons between Internet interventions (programmes):… (moderate certainty).

1 finding from 1 review

Intervention not reported

Comparisons between Internet interventions (messages): tailored/interactive versus not tailored/interactive Self‐reported smoking cessation · adults who want to stop smoking

The intervention showed no clear difference in comparisons between Internet interventions (messages):… (low certainty).

1 finding from 1 review