Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

340 questions · 340 findings · 22 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 141 · 41.5%GRADE not reported 8 · 2.4%Very low 98 · 28.8%Low 57 · 16.8%Moderate 29 · 8.5%High 7 · 2.1%

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… probably leads to lower number of postoperative bleeding episodes requiring intervention compared with placebo, no intervention or usual care (with or without placebo) (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ self‐selected music vs no music

Adherence · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes adherence to treatment Morisky‐Green questionnaire (number of… compared with no music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ self‐selected music vs no music

Frequency of hospitalisation for respiratory infection · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes frequency of hospitalisation for respiratory infection compared with no music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ specifically‐composed music vs no music

Adherence · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes adherence to treatment Morisky‐Green questionnaire (number of… compared with no music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ specifically‐composed music vs self‐selected music

Adherence · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes adherence to treatment Morisky‐Green questionnaire (number of… compared with self‐selected music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ specifically‐composed music vs self‐selected music

Frequency of hospitalisation for respiratory infection · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes frequency of hospitalisation for respiratory infection compared with self‐selected music (very low certainty).

1 finding from 1 review