Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

127 questions · 134 findings · 19 reviews · Emergency and Critical Care

No studies found 22 · 16.4%GRADE not reported 2 · 1.5%Very low 51 · 38.1%Low 41 · 30.6%Moderate 10 · 7.5%High 8 · 6%

Bispectral index vs treatment guided by clinical assessment alone?

Duration of mechanical ventilation · Mechanically ventilated adults in the intensive care unit

BIS monitoring showed no clear difference in duration of mechanical ventilation (measured in days) compared with clinical assessment (low certainty).

1 finding from 1 review

Intervention not reported

Combined mortality of all studies · Adult patients in intensive care

The intervention leads to higher combined mortality of all studies (high certainty).

1 finding from 1 review

Automated monitoring systems vs usual care

Time to initiation of antimicrobial therapy (Time to initiation starts at the time of admission) · people admitted to intensive care units

It is very uncertain whether automated monitoring systems changes time to initiation of antimicrobial therapy (Time to initiation… compared with standard care (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU

It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU

It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Myocardial infarction · adults admitted to the ICU

It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Stroke · adults admitted to the ICU

It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU

It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review