Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

169 questions · 174 findings · 18 reviews · Skin

No studies found 53 · 30.5%GRADE not reported 13 · 7.5%Very low 23 · 13.2%Low 41 · 23.6%Moderate 34 · 19.5%High 10 · 5.7%

Minoxidil vs placebo

Proportion of participants with self‐rated clinically significant hair regrowth · women with FPHL

Minoxidil probably leads to higher the proportion of participants with self‐rated clinically… compared with placebo (moderate certainty).

1 finding from 1 review

Minoxidil vs placebo

Proportion of participants with investigator‐rated clinically significant hair regrowth · women with FPHL

Minoxidil probably leads to higher proportion of participants with investigator‐rated clinically… compared with placebo (moderate certainty).

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants achieving a 50% reduction in disease severity · chronic palmoplantar pustulosis

Alitretinoin showed no clear difference in proportion of participants achieving a 50% reduction in disease… compared with placebo (moderate certainty).

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Alitretinoin showed no clear difference in proportion of participants with adverse effects ‐ measured over 24… compared with placebo (moderate certainty).

1 finding from 1 review