Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

219 questions · 223 findings · 25 reviews · Eyes and Vision

No studies found 76 · 34.1%GRADE not reported 5 · 2.2%Very low 39 · 17.5%Low 75 · 33.6%Moderate 25 · 11.2%High 3 · 1.3%

Intervention not reported

Incidence of overt retinopathya,b · people with type 2 diabetes

The intervention showed no clear difference in incidence of overt retinopathya,b (moderate certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Secondary hemorrhage at any time point · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in secondary hemorrhage at any time point compared with placebo (low certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in long‐term visual acuity 20/40 or better > 2 months after treatment compared with placebo (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Final visual acuity 20/40 or better at resolution of hyphema · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in final visual acuity 20/40 or better at resolution of hyphema compared with placebo (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Adverse event nausea and vomiting (0 to 24 hours) · people with traumatic hyphema

Systemic aminocaproic acid probably leads to higher adverse effects: nausea or vomiting compared with placebo (moderate certainty).

1 finding from 1 review