Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

294 questions · 295 findings · 16 reviews · Schizophrenia

No studies found 79 · 26.8%GRADE not reported 32 · 10.8%Very low 99 · 33.6%Low 55 · 18.6%Moderate 17 · 5.8%High 13 · 4.4%

HALOPERIDOL vs ARIPIPRAZOLE

Global outcome ‐ need for benzodiazepine during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Adverse effects: any serious, specific ‐ dystonia during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: any serious, specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Tranquil or asleep: Not tranquil or asleep · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep Not tranquil or asleep compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review