Question · asked by 1 review

HALOPERIDOL vs PLACEBO/NIL: Tranquilisation or asleep not asleep at 2 hours

Population
patients with psychosis‐induced aggression or agitation
Intervention
HALOPERIDOL
Comparison
PLACEBO/NIL
Outcome
Tranquilisation or asleep not asleep at 2 hours

It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep not asleep at 2 hours compared with PLACEBO/NIL (very low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
HALOPERIDOL vs PLACEBO/NIL
Tranquillisation or asleep not asleep at 2 hours · patients with psychosis‐induced aggression or agitation
It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep not asleep at 2 hours compared with PLACEBO/NIL (very low certainty).
Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) (2017) · Cochrane Headline outcomes only
RR 0.88 [0.82, 0.95]2 studies · 220 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation)
2017 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.