Findings

What do systematic reviews say?

679 questions · 687 findings · 43 reviews

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No studies found 169 · 24.6%GRADE not reported 172 · 25%Very low 157 · 22.9%Low 128 · 18.6%Moderate 47 · 6.8%High 14 · 2%

Local anaesthesia vs general anaesthesia

Any stroke within 30 days of operation (primary outcome) · patients with symptomatic or asymptomatic carotid disease

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
0.91 [0.66, 1.26]
13 studies · 4663 participants
Moderate

Local anaesthesia vs general anaesthesia

Death within 30 days of operation · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in death within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.61 [0.35, 1.06]
12 studies · 4421 participants
Low

Local anaesthesia vs general anaesthesia

Perioperative ipsilateral stroke (< 30 days) · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in ipsilateral stroke within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 1.03 [0.71, 1.48]
2 studies · 3733 participants
Low

Local anaesthesia vs general anaesthesia

Perioperative death and strokes · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in stroke or death within 30 days of operation compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.85 [0.62, 1.16]
11 studies · 4391 participants
Moderate

Local anaesthesia vs general anaesthesia

Myocardial infarction (0 to 30 days) · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in myocardial infarction within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 1.53 [0.67, 3.47]
12 studies · 4567 participants
Low

Local anaesthesia vs general anaesthesia

Local haemorrhage · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in local haemorrhage compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.99 [0.79, 1.25]
6 studies · 4186 participants
Moderate

Local anaesthesia vs general anaesthesia

Arteries shunted · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia may leads to lower arteries shunted compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.25 [0.22, 0.29]
8 studies · 4133 participants
Low

Intervention not reported

Block success (supplementation or conversion to general anaesthesia · People undergoing upper and lower limb blocks

The intervention probably leads to lower block success (supplementation or conversion to general anaesthesia (moderate certainty).

1 finding from 1 review

Ultrasound guidance for upper and lower limb blocks 2015 · Cochrane Headline outcomes only
OR 0.28 [0.2, 0.39]
18 studies · 1807 participants
Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

Continuation of status requiring a different drug or general anaesthesia · patients with status epilepticus

Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).

1 finding from 1 review

Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
RR 0.63 [0.45, 0.88]
3 studies · 264 participants
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · breast cancer surgery

Paravertebral anaesthesia with or without sedation may leads to lower postoperative analgesic requirement compared with general anaesthesia (low certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
OR 0.07 [0.01, 0.34]
5 studies · 305 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Number of patients with postoperative nausea and vomiting (postoperative care unit) · breast cancer surgery

Paravertebral anaesthesia with or without sedation probably leads to lower postoperative nausea and vomiting (PONV) compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
OR 0.16 [0.08, 0.3]
6 studies · 323 participants
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 2 hours · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 224 participants
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 24 hours on rest · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 169 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 6 hours on movement · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Pain (VAS scores) on movement at postoperative day 1 Scale from: 0 to 10. · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

All‐cause mortality · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 9 participants
GRADE not reported

Early removal of the LMA vs late removal of the LMA after general anaesthesia

Laryngospasm · patients with general anaesthesia

Early removal of the LMA showed no clear difference in laryngospasm (immediate) compared with late removal of the LMA after general anaesthesia (low certainty).

1 finding from 1 review

Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia 2015 · Cochrane Headline outcomes only
RR 1.23 [0.74, 2.03]
11 studies · 1615 participants
Low

Early removal of the LMA vs late removal of the LMA after general anaesthesia

Desaturation (immediate) · patients with general anaesthesia

It is very uncertain whether early removal of the LMA changes desaturation (immediate) compared with late removal of the LMA after general anaesthesia (very low certainty).

1 finding from 1 review

Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia 2015 · Cochrane Headline outcomes only
RR 0.68 [0.4, 1.16]
13 studies · 2037 participants
Very low

Early removal of the LMA vs late removal of the LMA after general anaesthesia

Airway obstruction (immediate) · patients with general anaesthesia

Early removal of the LMA may leads to higher airway obstruction (immediate) compared with late removal of the LMA after general anaesthesia (low certainty).

1 finding from 1 review

Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia 2015 · Cochrane Headline outcomes only
RR 2.69 [1.32, 5.5]
8 studies · 1313 participants
Low

Early removal of the LMA vs late removal of the LMA after general anaesthesia

Coughing (immediate) · patients with general anaesthesia

It is very uncertain whether early removal of the LMA changes coughing (immediate) compared with late removal of the LMA after general anaesthesia (very low certainty).

1 finding from 1 review

Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia 2015 · Cochrane Headline outcomes only
RR 0.52 [0.29, 0.94]
11 studies · 1430 participants
Very low