Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 475 findings · 59 reviews · Headline outcomes only

No studies found 112 · 23.6%GRADE not reported 13 · 2.7%Very low 66 · 13.9%Low 140 · 29.5%Moderate 112 · 23.6%High 32 · 6.7%

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + thiazolidinedione

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + thiazolidinedione compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + nateglinide
4 findings from 1 review
Show 1 more finding

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + SGLT2‐I

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + SGLT2‐I compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Aromatherapy vs placebo

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

It is very uncertain whether aromatherapy changes nausea duration (nausea‐free at end of treatment) Assessed by… compared with placebo (very low certainty).

1 finding from 1 review

Aromatherapy vs placebo

Rescue antiemetic · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

Aromatherapy may leads to lower proportion requiring rescue antiemetics Assessed by numbers of… compared with placebo (low certainty).

1 finding from 1 review

Aromatherapy vs placebo

Patient satisfaction with treatment Measured by a validated scale · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review