Cochrane · systematic review · CD012559
Hormone replacement therapy after surgery for epithelial ovarian cancer
Saeaib, N, Peeyananjarassri, K, Liabsuetrakul, T, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 5 · 62.5%Low 2 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hormone replacement therapy (HRT) compared to no HRT for women who have undergone surgery for epithelial ovarian cancer (EOC)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hormone replacement therapy (HRT) vs no HRT | HR 0.71 [0.54, 0.93] | 3 studies · 350 participants | Low Downgraded: risk of bias, inconsistency |
Quality of life, general condition Hormone replacement therapy (HRT) vs no HRT | no estimate extracted | 1 study · 75 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival Hormone replacement therapy (HRT) vs no HRT | HR 0.76 [0.57, 1.01] | 2 studies · 275 participants | Low Downgraded: risk of bias, inconsistency |
Incidence of breast cancer Hormone replacement therapy (HRT) vs no HRT | RR 2 [0.19, 21.59] | 2 studies · 225 participants | Very low Downgraded: risk of bias, imprecision |
Incidence of transient ischaemic attack Hormone replacement therapy (HRT) vs no HRT | RR 5 [0.24, 102.42] | 1 study · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of cerebrovascular accident Hormone replacement therapy (HRT) vs no HRT | RR 0.67 [0.11, 3.88] | 1 study · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of myocardial infarction Hormone replacement therapy (HRT) vs no HRT | RR 0.2 [0.01, 4.1] | 1 study · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of gallstones Hormone replacement therapy (HRT) vs no HRT | no estimate extracted | NR | No studies |