Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

265 questions · 280 findings · 26 reviews

No studies found 68 · 24.3%GRADE not reported 18 · 6.4%Very low 79 · 28.2%Low 57 · 20.4%Moderate 42 · 15%High 16 · 5.7%

Zinc vs placebo

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

BMD Z score (total hip/femoral neck) · people with β‐thalassaemia and osteoporosis

It is very uncertain whether the intervention changes BMD Z score (total hip/femoral neck) (very low certainty).

1 finding from 1 review

Vitamin D vs placebo or control

Femoral neck bone mineral density (FN-BMD) · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in femoral neck, Community-dwelling adults: WMD 1.10 (95% CI 0.40 to 1.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Short‐term mortality (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in short‐term mortality (30‐day or in‐hospital) compared with cut‐down femoral artery access (low certainty).

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Failure of aneurysm exclusion ( · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in failure of aneurysm exclusion( compared with cut‐down femoral artery access (moderate certainty).

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Wound infection · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in wound infection (30‐day or in‐hospital) compared with cut‐down femoral artery access (moderate certainty).

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Major complications · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in major complications (30‐day or in‐hospital) compared with cut‐down femoral artery access (moderate certainty).

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Medium‐ to long‐term complications( · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in medium‐ to long‐term complications( compared with cut‐down femoral artery access (moderate certainty).

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Bleeding complications (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in bleeding complications (30‐day or in‐hospital) compared with cut‐down femoral artery access (moderate certainty).

1 finding from 1 review