Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

62 questions · 62 findings · 1 reviews · HIV/AIDS

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 12.9%Low 24 · 38.7%Moderate 28 · 45.2%High 2 · 3.2%

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 12 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers may leads to lower HIV transmission at 12 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 12 months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 12 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission or Death at 6 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers probably leads to lower HIV transmission or Death at 12 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (moderate certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission at 6 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to lower infant Mortality at 6 months among those whose HIV diagnostic… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks probably leads to lower HIV Transmission or Death at 6 months among those whose HIV… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Persistance of Genotypic Resistance to NVP at 6 months among Ugandan infants found to be resistant at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher persistance of Genotypic Resistance to NVP at 6 months among Ugandan… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Indian infants HIV‐infected in utero or through peripartum/early‐breastfeeding transmission Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Indian infants HIV‐infected in… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Indian infants HIV‐infected through late breastfeeding Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in genotypic Resistance to NVP among Indian infants HIV‐infected… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission at 12 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks probably leads to lower infant Mortality at 12 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission or Death at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission or Death at 12 months among those whose HIV… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks leads to lower HIV Transmission or Death at 9 months among those whose HIV… compared with sdNVP plus ZDV (1week) (high certainty).

1 finding from 1 review