Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

67 questions · 68 findings · 7 reviews · Headline outcomes only

No studies found 27 · 39.7%GRADE not reported 3 · 4.4%Very low 0 · 0%Low 9 · 13.2%Moderate 14 · 20.6%High 15 · 22.1%

Etanercept vs placebo

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

Etanercept showed no clear difference in proportion of participants cleared or almost cleared in the short… compared with placebo (low certainty).

1 finding from 1 review

Etanercept vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants achieving a 50% reduction in disease severity ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Percentage of participants reaching PASI 75 · people with paediatric psoriasis

Etanercept leads to higher PASI 75 Participants achieving a 75% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 50 · people with paediatric psoriasis

Etanercept leads to higher PASI 50 Participants achieving a 50% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PASI 90 · people with paediatric psoriasis

Etanercept leads to higher PASI 90 Participants achieving a 90% improvement in the Psoriasis… compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

PGA Participants achieving a PGA of 'clear' or 'almost clear' · people with paediatric psoriasis

Etanercept leads to higher PGA Participants achieving a PGA of 'clear' or 'almost clear' compared with placebo (high certainty).

1 finding from 1 review

Etanercept vs placebo

CDLQI Scores range from 0 to 30. Lower scores indicate better health‐related quality of life. Calculations are based on the change from baseline to week 12 in both groups · people with paediatric psoriasis
1 finding from 1 review

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) + DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (10 mg) · participants with rheumatoid arthritis

The intervention leads to lower etanercept (10 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept + DMARD vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept vs. DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept vs. DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept + DMARD vs. Etanercept · participants with rheumatoid arthritis

The intervention probably leads to higher etanercept + DMARD vs. Etanercept (moderate certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis
1 finding from 1 review