Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

39 questions · 43 findings · 5 reviews · Incontinence

No studies found 13 · 30.2%GRADE not reported 0 · 0%Very low 17 · 39.5%Low 9 · 20.9%Moderate 4 · 9.3%High 0 · 0%

Prophylactic antibiotics vs placebo or no treatment

Febrile morbidity · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of women with febrile morbidity at hospital discharge compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo or no treatment

Mesh exposure · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of mesh exposures within six weeks after the operation compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Alarm vs placebo drug

Proportion of children achieving 14 consecutive dry nights by the end of treatment · children with nocturnal enuresis

Alarm may leads to higher proportion of children achieving 14 consecutive dry nights by the… compared with placebo drug (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (very low certainty).

2 findings from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy (reassurance, retention control training + wakening, parental involvement) · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy + motivation/counselling + education · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Intervention not reported

Number of wet nights per week at the end of treatment ‐ imipramine + oxybutynin vs imipramine · children with nocturnal enuresis
1 finding from 1 review

Tricyclic antidepressants vs placebo

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with placebo (very low certainty).

2 findings from 1 review

Intervention not reported

Number of wet nights per week at the end of treatment ‐ Amitriptyline + desmopressin vs amitriptyline · children with nocturnal enuresis
1 finding from 1 review

Intervention not reported

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine + oxybutynin vs placebo · children with nocturnal enuresis

The intervention probably leads to lower number not achieving 14 consecutive dry nights at the end of… (moderate certainty).

1 finding from 1 review