Tricyclic antidepressants vs placebo: Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo
It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tricyclics vs placebo Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs placebo · children with nocturnal enuresis It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with placebo (very low certainty). Tricyclic and related drugs for nocturnal enuresis in children (2016) · Cochrane Headline outcomes only | RR 0.74 [0.61, 0.9] | 12 studies · 831 participants | Very low |
Tricyclics vs placebo Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis Tricyclics may leads to lower number not achieving 14 consecutive dry nights at the end of… compared with placebo (low certainty). Tricyclic and related drugs for nocturnal enuresis in children (2016) · Cochrane Headline outcomes only | RR 0.83 [0.72, 0.97] | 2 studies · 98 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tricyclic and related drugs for nocturnal enuresis in children 2016 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.