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Evidence found and GRADE certainty

44 questions · 44 findings · 2 reviews · Skin

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No studies found 16 · 36.4%GRADE not reported 0 · 0%Very low 4 · 9.1%Low 5 · 11.4%Moderate 4 · 9.1%High 15 · 34.1%

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline vs prednisolone

Treatment‐related mortality at 1 year (mITT) · bullous pemphigoid

Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Quality of life (DLQI) adjusted for baseline DLQI, disease severity, age, Karnovsky score, baseline versus week 52. A lower score is more favourable. · bullous pemphigoid
1 finding from 1 review

Doxycycline vs prednisolone

Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid

Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Disease control · bullous pemphigoid

Doxycycline leads to lower disease control at 6 weeks (unadjusted raw data) compared with prednisolone (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher participant‐assessed improvement in rosacea severity1 Good to… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher physician‐assessed improvement in rosacea severity1 Complete… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Assessment of erythema or telangiectasia Improved or healed · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Azithromycin vs doxycycline

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azithromycin vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

It is very uncertain whether azithromycin changes participant‐assessed improvement in rosacea severity compared with doxycycline 100 mg (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

It is very uncertain whether azithromycin changes proportion of participants with adverse event compared with doxycycline 100 mg (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Physician‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review