Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Time needed until improvement of the skin lesions · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Findings
What do systematic reviews say?
173 questions · 174 findings · 12 reviews · Headline outcomes only
No studies found 34 · 19.5%GRADE not reported 26 · 14.9%Very low 34 · 19.5%Low 40 · 23%Moderate 25 · 14.4%High 15 · 8.6%
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Duration of remission ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg vs placebo
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg vs placebo
Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg vs placebo
Proportion of participants with adverse event · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Doxycycline 40 mg vs placebo
Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Doxycycline 40 mg vs placebo
Assessment of erythema or telangiectasia · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Doxycycline 40 mg vs placebo
Lesion count · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsModerate
Doxycycline 40 mg vs placebo
Time needed until improvement of the skin lesions · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Doxycycline 40 mg vs placebo
Duration of remission ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline vs prednisolone
Treatment‐related mortality at 1 year (mITT) · bullous pemphigoid
Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).
1 finding from 1 review
- RR 0.25 [0.07, 0.89]1 study · 234 participantsModerate
Doxycycline vs prednisolone
Quality of life (DLQI) adjusted for baseline DLQI, disease severity, age, Karnovsky score, baseline versus week 52. A lower score is more favourable. · bullous pemphigoid
1 finding from 1 review
- no estimate extracted1 study · 234 participantsHigh
Doxycycline vs prednisolone
Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid
Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).
1 finding from 1 review
- RR 0.59 [0.35, 0.99]1 study · 234 participantsModerate
Doxycycline vs prednisolone
Disease control · bullous pemphigoid
Doxycycline leads to lower disease control at 6 weeks (unadjusted raw data) compared with prednisolone (high certainty).
1 finding from 1 review
- RR 0.81 [0.72, 0.92]1 study · 213 participantsHigh
Doxycycline vs quinolones
Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).
1 finding from 1 review
- Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non‐pregnant women 2019 · Cochrane Headline outcomes onlyRR 1.02 [0.66, 1.55]3 studies · 339 participantsVery low
Doxycycline vs quinolones
Antimicrobial resistance · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non‐pregnant women 2019 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Doxycycline vs quinolones
Reinfection · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non‐pregnant women 2019 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Doxycycline vs tetracycline
Treatment failure · adults with scrub typhus
It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).
1 finding from 1 review
- RR 6.85 [0.38, 124.38]1 study · 116 participantsVery low
Doxycycline vs tetracycline
Resolution of fever within 48 hours · adults with scrub typhus
Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).
1 finding from 1 review
- RR 1.14 [0.9, 1.44]1 study · 55 participantsLow
Doxycycline vs tetracycline
Resolution of fever within 5 days · adults with scrub typhus
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found