Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, digital bitewing radiography (phosphor plates) pooled specificity was 0.95 (95% CI 0.59 to 0.995) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.95 [0.59, 0.995]
2 studies
GRADE not reported
AUC 0.73
2 studies
GRADE not reported
Sensitivity 0.48 [0.24, 0.73]
2 studies
GRADE not reported
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DOR 15.57 [0.47, 515.27]
2 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, visual examination pooled specificity was 0.77 (95% CI 0.67 to 0.85) for occlusal caries at the 1/3 dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.77 [0.67, 0.85]
3 studies
GRADE not reported
Sensitivity 0.72 [0.52, 0.86]
3 studies
GRADE not reported
DOR 10.18 [3.94, 26.29]
3 studies
GRADE not reported
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AUC 0.77
3 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (E-speed) pooled diagnostic odds ratio was 127.56 (95% CI 7.38 to 2203.70) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
DOR 127.56 [7.38, 2203.70]
2 studies
GRADE not reported
Specificity 0.98 [0.79, 0.998]
2 studies
GRADE not reported
AUC 0.90
2 studies
GRADE not reported
Show 1 more finding
Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, visual examination pooled diagnostic odds ratio was 16.6 (95% CI 4.85 to 56.79) for occlusal caries at the 1/3 dentin detection level; ungraded.
4 findings from 1 review
DOR 16.6 [4.85, 56.79]
2 studies
GRADE not reported
Specificity 0.88 [0.83, 0.92]
2 studies
GRADE not reported
Sensitivity 0.69 [0.51, 0.82]
2 studies
GRADE not reported
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AUC 0.89
2 studies
GRADE not reported
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (F-speed) pooled specificity was 0.97 (95% CI 0.71 to 0.998) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Show 1 more finding
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, conventional bitewing radiography (D-speed) pooled specificity was 0.73 (95% CI 0.53 to 0.87) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
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Arrest of dentine caries · Preschool children with active dentine caries in primary teeth (mean age 3.4-4.0 years)
Silver diamine fluoride was about 2.5 times more likely than sodium fluoride to arrest dentine caries surfaces at 18 months (pooled OR 2.51, 95% CI 1.25 to 5.10; 2 RCTs), although between-study heterogeneity was high (I2=90.3%); certainty of evidence was not formally graded.
2 findings from 1 review
Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Pulp exposure rate · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal was associated with a lower mean pulp exposure rate than conventional removal (1.2% vs 8.1%), but the difference was not statistically significant (Wilcoxon, p = 0.068); certainty of evidence was not graded.
1 finding from 1 review
Mean pulp-exposure percentage (unweighted study-level mean, 4 studies) MIT 1.2% vs CT 8.1% (Wilcoxon = 0.0, p = 0.068; not statistically significant)
4 studies · 791 participants
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal showed a marginally higher mean restoration success rate than conventional removal (83.6% vs 75.4%), but the difference was not statistically significant (Mann-Whitney U, p > 0.05); certainty of evidence was not graded.
1 finding from 1 review
Mean success-rate percentage (unweighted study-level mean, 7 studies) MIT 83.6% vs CT 75.4% (Mann-Whitney U = 0.2, p > 0.05; not statistically significant)
7 studies · 1305 participants
GRADE not reported
Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Cathepsin K (CT-K) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin K may be increased in carious dentin (one study), but no certainty rating was assigned (ungraded).
1 finding from 1 review
Higher intensity of immunodetection of CT-K was registered in carious dentin than in sound dentin (Vidal et al., 2014); GRADE was not applied to CT-K.
1 study · 10 participants
GRADE not reported
MMP-8 expression/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
For MMP-8, no clear direction of difference between carious and sound dentin was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-2 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain.
7 studies · 373 participants
Very low
MMP-9 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-9 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-9 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain.
3 studies · 292 participants
Very low
MMP-13 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-13 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-13 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Loreto et al., 2014: more in coronal caries, p<0.05).
1 study · 13 participants
Very low
Cathepsin B (CT-B) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin B may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
CT-B may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Vidal et al., 2014; Nascimento et al., 2011: significantly higher in caries, p<0.05).
2 studies · 22 participants
Very low
Sensitivity for detection of enamel caries · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review
Specificity for detection of enamel caries · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review