Carious dentin vs Sound dentin: MMP-8 expression/activity
For MMP-8, no clear direction of difference between carious and sound dentin was found; the evidence is very uncertain (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Carious dentin vs Sound dentin MMP-8 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions · Ex vivo (extracted teeth / clinical carious or biofilm samples) For MMP-8, no clear direction of difference between carious and sound dentin was found; the evidence is very uncertain (very low certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | Due to the conflicting results of the included studies, no effect direction was found so the evidence is very uncertain regarding the MMP-8 presence in carious vs. sound dentin. | 2 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.