Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 12 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 5 · 17.2%GRADE not reported 0 · 0%Very low 4 · 13.8%Low 11 · 37.9%Moderate 6 · 20.7%High 3 · 10.3%

Three doses HPV vaccine vs control

Overall systemic events and general symptoms · 10‐ to 26‐year‐old males

Three doses HPV vaccine showed no clear difference in overall systemic events and general symptoms at 15‐day compared with control (moderate certainty).

1 finding from 1 review

Nonavalent HPV vaccine vs quadrivalent HPV vaccine

Overall local/injection site adverse events at 15‐day · 9‐ to 26‐year‐old females and males

Nonavalent HPV vaccine leads to higher overall local/injection site adverse events at 15‐day compared with quadrivalent HPV vaccine (high certainty).

1 finding from 1 review

Nonavalent HPV vaccine vs quadrivalent HPV vaccine

Overall systemic events and general symptoms · 9‐ to 26‐year‐old females and males

Nonavalent HPV vaccine showed no clear difference in overall systemic events and general symptoms at 15‐day compared with quadrivalent HPV vaccine (moderate certainty).

1 finding from 1 review