Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

182 questions · 183 findings · 20 reviews · Headline outcomes only

No studies found 46 · 25.1%GRADE not reported 5 · 2.7%Very low 51 · 27.9%Low 37 · 20.2%Moderate 34 · 18.6%High 10 · 5.5%

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Leaving the study early · Informal caregivers of people with dementia

Complex information, support and training interventions showed no clear difference in dropouts for any reason compared with usual treatment, waiting list or attention control informations (low certainty).

1 finding from 1 review

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Use of health and social resources · Informal caregivers of people with dementia

Complex information, support and training interventions showed no clear difference in use of health and social resources compared with usual treatment, waiting list or attention control informations (moderate certainty).

1 finding from 1 review

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Institutional care ‐ nursing home placement · Informal caregivers of people with dementia

It is very uncertain whether complex information, support and training interventions changes institutional care ‐ nursing home placement compared with usual treatment, waiting list or attention control informations (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death or dependence (mRS 4–6) compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes intracerebral haemorrhage expansion by 24 hours compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes all serious adverse events compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

Death from any cause · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death from any cause compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

'Treatment failure': various secondary procedures such as remanipulation for early loss of position; early or more complex wire removal ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes 'Treatment failure': various secondary procedures such as… compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR versus various controls · participants at risk of developing long‐term conditions

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Behavioural outcome: breast cancer screening Multimodal/complex intervention versus usual care at 12 months · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention leads to higher behavioural outcome: breast cancer screening Multimodal/complex… (high certainty).

1 finding from 1 review

Intervention not reported

Behavioural outcome: colorectal cancer screening Multimodal/complex intervention versus usual care at median · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention leads to higher behavioural outcome: colorectal cancer screening Multimodal/complex… (high certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional versus various controls · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review