Mean change in IOP from pre‐LTP within 2 hours · people with glaucoma receiving LTP
1 finding from 1 review
IOP increase of ≥ 5 mmHg between 2 and 24 hours · people with glaucoma receiving LTP
1 finding from 1 review
no estimate extracted
Studies not reported
Low
IOP increase of ≥ 10 mmHg between 2 and 24 hours · people with glaucoma receiving LTP
Apraclonidine showed no clear difference in IOP increase of ≥ 10 mmHg between 2 and 24 hours compared with pilocarpine (low certainty).
1 finding from 1 review
Mean change in IOP from pre‐LTP between 2 and 24 hours · people with glaucoma receiving LTP
1 finding from 1 review
Adverse events during treatment period · people with glaucoma receiving LTP
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 50% or greater · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in participant‐reported pain relief of 50% or greater during longest compared with placebo (low certainty).
1 finding from 1 review
Patient Global Impression of Change much or very much improved · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
PGIC very much improved · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Withdrawals due to adverse events · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants reporting an adverse event · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Lack of efficacy withdrawal · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 30% or greater · adults with painful diabetic neuropathy
It is very uncertain whether topical clonidine (TC) changes participant‐reported pain relief of 30% or greater during longest compared with placebo (very low certainty).
1 finding from 1 review
Patient Global Impression of Change much or very much improved · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in much or very much improved on PGIC during longest compared with placebo (low certainty).
1 finding from 1 review
PGIC very much improved · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in very much improved on PGIC during longest compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in withdrawals due to adverse events during longest compared with placebo (low certainty).
1 finding from 1 review
Number of participants reporting an adverse event · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in participants experiencing at least 1adverse event during longest compared with placebo (low certainty).
1 finding from 1 review
Lack of efficacy withdrawal · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in withdrawal due to lack of efficacy (12 weeks) compared with placebo (low certainty).
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · adults with painful diabetic neuropathy
Topical clonidine (TC) showed no clear difference in participant‐reported pain relief of 50% or greater during longest compared with active comparator (low certainty).
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · adults with painful diabetic neuropathy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment failure To discharge · newborn infants with opioid withdrawal
It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with opioid alone (very low certainty).
1 finding from 1 review