Topical clonidine (TC) vs placebo: Participant‐reported pain relief of 30% or greater
- Population
- adults with painful diabetic neuropathy
- Intervention
- Topical clonidine (TC)
- Comparison
- placebo
- Outcome
- Participant‐reported pain relief of 30% or greater
It is very uncertain whether topical clonidine (TC) changes participant‐reported pain relief of 30% or greater during longest compared with placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Topical clonidine (TC) vs placebo Participant‐reported pain relief of 30% or greater during longest · adults with painful diabetic neuropathy It is very uncertain whether topical clonidine (TC) changes participant‐reported pain relief of 30% or greater during longest compared with placebo (very low certainty). Topical clonidine for neuropathic pain in adults (2022) · Cochrane Headline outcomes only | RR 1.35 [1.03, 1.77] | 2 studies · 344 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Topical clonidine for neuropathic pain in adults 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Topical clonidine (TC) vs active comparators · adults with painful diabetic neuropathy · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.