Serious adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension
Naltrexone/bupropion showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
All adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension
Naltrexone/bupropion probably leads to higher all adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Change in systolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Change in diastolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Change in body weight as compared to placebo [kg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in dropouts due to treatment compared with NRT alone (low certainty).
1 finding from 1 review
Intervention not reported
Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe
It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).
1 finding from 1 review
RR 0.77 [0.42, 1.41]
121 participants
Very low
Intervention not reported
Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe
It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).
1 finding from 1 review
RR 1.94 [0.94, 4]
86 participants
Very low
Intervention not reported
Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention showed no clear difference in bupropion (moderate certainty).
1 finding from 1 review
Intervention not reported
Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention leads to higher bupropion (high certainty).
1 finding from 1 review
Intervention not reported
Bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention
The intervention showed no clear difference in bupropion versus placebo Smoking cessation (moderate certainty).
1 finding from 1 review
Intervention not reported
Combination NRT & bupropion versus placebo Smoking cessation · people who have quit smoking using a cessation intervention
The intervention showed no clear difference in combination NRT & bupropion versus placebo Smoking cessation (low certainty).
1 finding from 1 review
Subgroup: bupropion only; smoking cessation (≥ 6 month · people who smoke
Reduction and pharmacotherapy showed no clear difference in subgroup: bupropion only; smoking cessation (≥ 6 month compared with reduction alone (low certainty).
1 finding from 1 review
Smoking cessation · young people
It is very uncertain whether pharmacological interventions changes bupropion vs placebo Smoking cessation compared with placebo (very low certainty).
2 findings from 1 review
Adverse events (control ‐ placebo) · young people
2 findings from 1 review