Findings

What do systematic reviews say?

31 questions · 31 findings · 5 reviews · Headline outcomes only

Sort:Best matchNewest Highest certainty Download CSV

No studies found 3 · 9.7%GRADE not reported 0 · 0%Very low 5 · 16.1%Low 10 · 32.3%Moderate 10 · 32.3%High 3 · 9.7%

Plain lidocaine vs buffered lidocaine

Personal preference · Patients requiring local anaesthesia

Plain lidocaine leads to higher preference compared with buffered lidocaine (high certainty).

1 finding from 1 review

Adjusting the pH of lidocaine for reducing pain on injection 2010 · Cochrane Headline outcomes only
OR 3.01 [1.19, 4.15]
8 studies · 346 participants
High

Plain lidocaine vs buffered lidocaine

Adverse events · Patients requiring local anaesthesia

1 finding from 1 review

Adjusting the pH of lidocaine for reducing pain on injection 2010 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 182 participants
High

Intervention not reported

Mortality · patients with acute kidney injury

The intervention showed no clear difference in mortality (moderate certainty).

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
RR 0.76 [0.5, 1.15]
3 studies · 163 participants
Moderate

Intervention not reported

Serum bicarbonate (mmol/L) · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 163 participants
Low

Intervention not reported

Serum creatinine (µmol/L) · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 137 participants
Low

Intervention not reported

Serum lactate (mmol/L) · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 171 participants
Moderate

Intervention not reported

Serum base excess · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 145 participants
Low

Intervention not reported

Serum pH · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 171 participants
Low

Intervention not reported

pCO2 · patients with acute kidney injury

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 151 participants
Low

Intervention not reported

Hypotensive events · patients with acute kidney injury

The intervention probably leads to lower hypotensive events (moderate certainty).

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
RR 0.44 [0.26, 0.75]
1 study · 20 participants
Moderate

Intervention not reported

Cardiovascular complications · patients with acute kidney injury

The intervention probably leads to lower cardiovascular complications (moderate certainty).

1 finding from 1 review

Bicarbonate‐ versus lactate‐buffered solutions for acute continuous haemodiafiltration or haemofiltration 2015 · Cochrane Headline outcomes only
RR 0.39
1 study · 20 participants
Moderate