What do systematic reviews say?

Discontinuation vs continuation of antipsychotic medication

Discontinuation may leads to lower success of withdrawal from antipsychotics compared with continuation of antipsychotic medication (low certainty).

• Withdrawal versus continuation of long‐term antipsychotic drug use for behavioural and psychological symptoms in older… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 575 participants
  Low

Typical vs atypical antipsychotics

Typical showed no clear difference in mortality compared with atypical antipsychotics (moderate certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 1.71 [0.82, 3.53]
  4 studies · 342 participants
  Moderate

Typical vs atypical antipsychotics

The review found no eligible studies for this question.

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Typical vs atypical antipsychotics

It is very uncertain whether typical changes adverse Effects ‐ EPS compared with atypical antipsychotics (very low certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 12.16 [0.55, 269.52]
  2 studies · 198 participants
  Very low

Typical vs atypical antipsychotics

The review found no eligible studies for this question.

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Typical vs atypical antipsychotics

Typical showed no clear difference in delirium resolution DRS, DRS‐R981 compared with atypical antipsychotics (moderate certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 1.1 [0.79, 1.52]
  5 studies · 349 participants
  Moderate

Typical vs atypical antipsychotics

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 542 participants
  Moderate

Benzodiazepines (lorazepam) vs chlorpromazine

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (chlorpromazine) (very low certainty).

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  RR 0.87 [0.23, 3.26]
  1 study · 19 participants
  Very low

Benzodiazepines (lorazepam) vs haloperidol

The review found no eligible studies for this question.

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Benzodiazepines (lorazepam) vs haloperidol

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Benzodiazepines (lorazepam) vs haloperidol

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Benzodiazepines (lorazepam) vs haloperidol

The review found no eligible studies for this question.

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Benzodiazepines (lorazepam) vs haloperidol

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (haloperidol) (very low certainty).

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  RR 1.83 [0.34, 9.92]
  1 study · 17 participants
  Very low

Benzodiazepines (lorazepam) vs chlorpromazine

The review found no eligible studies for this question.

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Benzodiazepines (lorazepam) vs chlorpromazine

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 19 participants
  Very low

Benzodiazepines (lorazepam) vs chlorpromazine

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 19 participants
  Very low

Benzodiazepines (lorazepam) vs chlorpromazine

The review found no eligible studies for this question.

• Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found