Findings

What do systematic reviews say?

54 questions · 54 findings · 8 reviews · Cystic Fibrosis and Genetic Disorders

Sort:Best matchNewest Highest certainty Download CSV

No studies found 17 · 31.5%GRADE not reported 5 · 9.3%Very low 5 · 9.3%Low 9 · 16.7%Moderate 18 · 33.3%High 0 · 0%

Digital technology (web‐based platform CFHealthHub) vs usual care

QoL · adults (aged 16 years and over) with CF

Digital technology (web‐based platform CFHealthHub) showed no clear difference in qoL: CFQ‐R domain scores at end of study compared with usual care (moderate certainty).

1 finding from 1 review

Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 3.2
1 study · 538 participants
Moderate

Digital technology (web‐based platform CFHealthHub) vs usual care

FEV1 % predicted · adults (aged 16 years and over) with CF

Digital technology (web‐based platform CFHealthHub) showed no clear difference in FEV1: mean FEV1 % predicted at end of study compared with usual care (low certainty).

1 finding from 1 review

Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 3.7
1 study · 556 participants
Low

Psychological interventions vs active comparators

QoL · adults (aged 16 years and over) with CF

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 95 participants
Very low

Psychological interventions vs active comparators

FEV1 % predicted · adults (aged 16 years and over) with CF

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 125 participants
Very low

Psychological interventions vs active comparators

Pulmonary exacerbations · adults (aged 16 years and over) with CF

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Very low

Psychological interventions vs active comparators

Adherence to inhaled therapies cMPR · adults (aged 16 years and over) with CF

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 95 participants
Very low

Psychological interventions vs active comparators

Anxiety (adverse effect, post‐intervention) · adults (aged 16 years and over) with CF

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Psychological interventions vs active comparators

Treatment‐related adverse events Depression · adults (aged 16 years and over) with CF

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liprotamase vs porcine PERT

Change in weight (kg) · children aged 7 years or over and adults with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Low

Summary of findings: liprotamase vs porcine PERT

Change in height · children aged 7 years or over and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liprotamase vs porcine PERT

Change in BMI · children aged 7 years or over and adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liprotamase vs porcine PERT

Abdominal pain frequency or change in frequency · children aged 7 years or over and adults with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Low

Summary of findings: liprotamase vs porcine PERT

CFA: change from baseline (%) · children aged 7 years or over and adults with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Low

Summary of findings: liprotamase vs porcine PERT

Adverse events · children aged 7 years or over and adults with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Low

Summary of findings: liprotamase vs porcine PERT

Pulmonary exacerbations · children aged 7 years or over and adults with cystic fibrosis

Summary of findings: liprotamase showed no clear difference in pulmonary exacerbations: number of exacerbations compared with porcine PERT (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
OR 0.56 [0.13, 2.45]
1 study · 128 participants
Low

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to next isolation of PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled probably leads to higher time to next isolation of PA compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
HR 2.04 [1.28, 3.26]
1 study · 253 participants
Moderate

Summary of findings: cycled vs culture‐based antibiotic therapy

Quality of life · children (aged 1 to 12 years) with CF and a newly isolated PA infection

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: cycled vs culture‐based antibiotic therapy

Lung function: FEV1 mL (change from baseline) · children (aged 1 to 12 years) with CF and a newly isolated PA infection

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 131 participants
Very low

Summary of findings: cycled vs culture‐based antibiotic therapy

Pulmonary exacerbations · children (aged 1 to 12 years) with CF and a newly isolated PA infection

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 253 participants
Moderate

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to chronic PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found