Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Training of health providers vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

It is very uncertain whether training of health providers changes proportion of children who received all recommended vaccines by 2… compared with routine care (very low certainty).

1 finding from 1 review

Home visit vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

It is very uncertain whether home visit changes proportion of children who received all recommended vaccines by 2… compared with routine care (very low certainty).

1 finding from 1 review

Immunisation outreach vs usual care

Proportion of children who received all recommended vaccines by 25 years of age · children under 5 years of age

It is very uncertain whether immunisation outreach changes proportion of children who received all recommended vaccines by 25… compared with routine care (very low certainty).

1 finding from 1 review

Immunisation outreach vs usual care

Fully immunised children ( · children under 5 years of age

Immunisation outreach probably leads to higher proportion of children under 5 years of age fully immunised with all… compared with routine care (moderate certainty).

2 findings from 1 review

Immunisation outreach vs usual care

Fully immunised ‐ regular immunisation outreach + non‐monetary incentive ( · children under 5 years of age

Immunisation outreach probably leads to higher proportion of children under 5 years of age fully immunised with all… compared with routine care (moderate certainty).

1 finding from 1 review

Health education vs usual care

Proportion of children under 5 years of age fully immunised with all scheduled vaccines · children under 5 years of age

Health education may leads to higher proportion of children under 5 years of age fully immunised with all… compared with routine care (low certainty).

1 finding from 1 review

Integration of immunisation with other health services vs usual care

Proportion of children who received all recommended vaccines by 2 years of age · children under 5 years of age

Integration of immunisation with other health services may leads to higher proportion of children who received all recommended vaccines by 2… compared with routine care (low certainty).

1 finding from 1 review

Extraction at patient age <8 years vs Extraction at patient age >10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction before age 8 (vs after 10) increases odds of space closure (OR 5.01; low certainty).

1 finding from 1 review

Age 8-10 years vs Extraction at patient age >10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).

1 finding from 1 review

Extraction at patient age 11-12 years vs Extraction at patient age 8-10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at 11-12 vs 8-10 years showed no significant difference in one analysis (OR 0.82; not GRADE-rated).

2 findings from 1 review

High Streptococcus mutans colonization in primary dentition (age 2-3 years) vs Lower Streptococcus mutans load

Caries (DMFT/DMFS) in mixed/permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Higher early Streptococcus mutans colonization is associated with more caries in the mixed/permanent dentition (2 studies; not pooled; not GRADE-rated).

1 finding from 1 review