Findings

What do systematic reviews say?

4,320 questions · 4,561 findings · 388 reviews

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No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating healthy snacks at least twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
2 to 4 years
Table 2: 71% (178) versus 68% (168) at follow-up (baseline 69% versus 65%). No significant change.
1 study · 497 participants
GRADE not reported

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

Adverse effects · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Any orthodontic and/or surgical treatment for Angle Class III malocclusion vs no intervention or another intervention

Correction of prominent lower front teeth / effectiveness of treatment (planned primary outcome) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for adults with prominent lower front teeth 2012 · Cochrane All outcomes
No included study measured the planned primary outcome. Discussion: 'The primary outcome proposed for this review was to evaluate the effectiveness of treatments for prognathism, but none of the studies conclusively…
Studies not reported
No studies found

HAART regimen + topical treatment vs HAART alone

Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
0 studies
No studies found

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

Adverse effects · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel)

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Intervention not reported

Clinical malaria · Children aged less than 5 years

The intervention leads to lower clinical malaria (high certainty).

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
Rate Ratio 0.26 [0.17, 0.38]
6 studies · 9321 participants
High

Intervention not reported

Severe malaria · Children aged less than 5 years

The intervention leads to lower severe malaria (high certainty).

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
Rate Ratio 0.27 [0.1, 0.76]
2 studies · 5964 participants
High

Intervention not reported

Death from any cause · Children aged less than 5 years

The intervention showed no clear difference in death from any cause (moderate certainty).

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
Risk Ratio 0.66 [0.31, 1.39]
6 studies · 9533 participants
Moderate

Intervention not reported

Moderately severe anaemia · Children aged less than 5 years

The intervention probably leads to lower moderately severe anaemia (moderate certainty).

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
Risk Ratio 0.71 [0.52, 0.98]
5 studies · 8805 participants
Moderate

Intervention not reported

Serious drug related adverse events · Children aged less than 5 years

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 9533 participants
Moderate

Intervention not reported

Non‐serious adverse events · Children aged less than 5 years

1 finding from 1 review

Intermittent preventive treatment for malaria in children living in areas with seasonal transmission 2012 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 9533 participants
Moderate

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5.25% with hydrogen peroxide 3% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with normal saline; GRADE not reported.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
RR 0.65 [0.2, 2.0]
1 study · 161 participants
GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating warm meals more than twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
2 to 4 years
Table 2: 77% (193) versus 81% (200) at follow-up (baseline 83% versus 74%, a significant baseline difference). No significant change at follow-up.
1 study · 497 participants
GRADE not reported

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% vs Normal saline

Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found