Search review questions

Duration of sensory block (we included all studies describing duration of sensory block regardless of how it was described) · participants undergoing surgery with peripheral nerve block

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

Postoperative pain intensity at 12 hours (measured using pain scores on an 11‐point VAS) · participants undergoing surgery with peripheral nerve block

Postoperative pain intensity at 24 hours (measured using pain scores on an 11‐point VAS) · participants undergoing surgery with peripheral nerve block

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

Need for ETT exchange (defined as more than one attempt to arrive at the final endotracheal tube size) · Children up to eight years undergoing general anaesthesia

Need for tracheal re‐intubation for postoperative stridor (defined as the need to re‐intubate to assure oxygenation to deal with postextubation stridor) · Children up to eight years undergoing general anaesthesia

Need for epinephrine to treat stridor (defined as the need to use epinephrine to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

Need for intensive care unit (ICU) admission to treat post extubation stridor (as defined by the trial authors) · Children up to eight years undergoing general anaesthesia

Cost of medical gas (described in the study by the hospital expenses for medical gases per participant in Euros) · Children up to eight years undergoing general anaesthesia

Need for corticosteroid to treat stridor (defined as the need to use corticosteroid to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

Recovery timea from second twitch (T2) to train‐of‐four ratio (TOFR) > 0.9 (moderate block) · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Bradycardia · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

PONV · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Overall signs of postoperative residual paralysis · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Risk of serious adverse eventsb · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Recovery timea from post‐tetanic count (PTC) · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Risks of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Recovery timea from second twitch (T2) to train‐of‐four ratio (TOFR) > 0.9 (moderate block) · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Recovery timea from post‐tetanic count (PTC 1 to 5) to train‐of‐four ratio (TOFR) > 0.9 (deep block) · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Risk of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · adult patients, ASA I to IV, who received non‐depolarizing NMBAs

Recovery timea from second twitch (T2) to train‐of‐four ratio (TOFR) > 0.9 (moderate block) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Recovery timea from post‐tetanic count (PTC) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Risk of composite adverse eventsb · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Mortality · Patients with hip fracture repair

Pneumonia · Patients with hip fracture repair

Myocardial infarction · Patients with hip fracture repair

Cerebrovascular accident · Patients with hip fracture repair

Acute confusional state · Patients with hip fracture repair

Deep vein thrombosis · Patients with hip fracture repair

Return of patient to their own home · Patients with hip fracture repair

Time required to observe first flatus · adults

Time required to observe first faeces · adults

VAS scores on movement at 24 hours · adults

Vomiting during first 24 hours · adults

Anastomotic leak · adults

Length of hospital stay · adults

All‐cause mortality Advanced haemodynamic monitoring · patients with proximal femoral fracture

Medically fit for discharge · patients with perioperative fluid optimization

Return to pre‐fracture accommodation/return to pre‐fracture mobility · patients with perioperative fluid optimization

Adverse outcomes ‐ cardiopulmonary · patients with perioperative fluid optimization

Adverse outcomes ‐ neurological · patients with perioperative fluid optimization

Adverse outcomes ‐ all · patients with perioperative fluid optimization

All‐cause mortality · patients with perioperative fluid optimization

Total length of hospital stay · patients with perioperative fluid optimization

Medically fit for discharge · patients with perioperative fluid optimization

Return to pre‐fracture accommodation/return to pre‐fracture mobility · patients with perioperative fluid optimization

Adverse outcomes ‐ cardiopulmonary · patients with perioperative fluid optimization

Total length of hospital stay · patients with proximal femoral fracture

Adverse outcomes ‐ neurological · patients with perioperative fluid optimization