Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

568 questions · 575 findings · 105 reviews

No studies found 53 · 9.2%GRADE not reported 26 · 4.5%Very low 91 · 15.8%Low 215 · 37.4%Moderate 151 · 26.3%High 39 · 6.8%

Ambroxol vs corticosteroid (betamethasone)

Perinatal mortality frequency of deaths of newborns · women at risk of preterm birth

Ambroxol showed no clear difference in perinatal mortality frequency of deaths of newborns compared with corticosteroid (betamethasone) (moderate certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Adverse effects in pregnant women frequency in pregnant women · women at risk of preterm birth

It is very uncertain whether ambroxol changes adverse effects in pregnant women frequency in pregnant women compared with corticosteroid (betamethasone) (very low certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Administration of pulmonary surfactant frequency in newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Administration of pulmonary surfactant… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Need for mechanical ventilation frequency inf newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Need for mechanical ventilation frequency… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Invasive infection prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention probably leads to higher invasive infection prior to hospital discharge (moderate certainty).

1 finding from 1 review