Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 412 findings · 45 reviews · Headline outcomes only

No studies found 137 · 33.3%GRADE not reported 8 · 1.9%Very low 129 · 31.3%Low 88 · 21.4%Moderate 47 · 11.4%High 3 · 0.7%

Silicone‐filled vs saline‐filled implants

Capsular contracture Number of women with capsular contracture · women having reconstructive breast surgery

It is very uncertain whether silicone‐filled changes capsular contracture Number of women with capsular contracture compared with saline‐filled implants (very low certainty).

1 finding from 1 review

Silicone‐filled vs saline‐filled implants

Patient satisfaction for consistency Number of women satisfied · women having reconstructive breast surgery

It is very uncertain whether silicone‐filled changes patient satisfaction for consistency Number of women satisfied compared with saline‐filled implants (very low certainty).

1 finding from 1 review

PVP‐hydrogel‐filled vs saline‐filled implants

Capsular contracture Number of women with capsular contracture · women having reconstructive breast surgery

It is very uncertain whether PVP‐hydrogel‐filled changes capsular contracture Number of women with capsular contracture compared with saline‐filled implants (very low certainty).

1 finding from 1 review

PVP‐hydrogel‐filled vs saline‐filled implants

Short‐term complications Number of women with at least one short‐term complication · women having reconstructive breast surgery

It is very uncertain whether PVP‐hydrogel‐filled changes short‐term complications Number of women with at least one… compared with saline‐filled implants (very low certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Injection site reactions ‐ induration ‐ swelling · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in injection site reactions ‐ induration ‐ swelling compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Systemic reactions ‐ fever (oral temperature ≥ 38°C) · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in systemic reactions ‐ fever (oral temperature ≥ 38°C) compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Systemic reactions ‐ headache · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in systemic reactions ‐ headache compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Systemic reactions ‐ malaise · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in systemic reactions ‐ malaise compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Systemic reactions ‐ myalgia · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in systemic reactions ‐ myalgia compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Injection site pain · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… probably leads to higher injection site reactions ‐ pain at injection site compared with saline placebo (moderate certainty).

1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Injection site reactions ‐ erythema ‐ redness · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in injection site reactions ‐ erythema ‐ redness compared with saline placebo (moderate certainty).

1 finding from 1 review

Lidocaine vs control (air/saline)

Sore throat · patients presenting with postoperative sore throat

lidocaine may leads to lower risk of sore throat 12 hours to 30 hours after the operation compared with control (air/saline) (low certainty).

2 findings from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin probably leads to lower rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11 Clinical diagnosis by 2 physicians · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11… compared with control (saline or no treatment) (low certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin leads to lower subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology… compared with control (saline or no treatment) (high certainty).

1 finding from 1 review

Gamma‐globulin vs control (no preparation or saline preparation)

Subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs · susceptible people exposed to rubella

Gamma‐globulin showed no clear difference in subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology… compared with control (saline or no treatment) (moderate certainty).

1 finding from 1 review