Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

508 questions · 529 findings · 58 reviews

No studies found 191 · 36.1%GRADE not reported 49 · 9.3%Very low 143 · 27%Low 92 · 17.4%Moderate 51 · 9.6%High 3 · 0.6%

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

Periodontal healing at 48 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes periodontal healing at 48 months compared with control (saline) (very low certainty).

1 finding from 1 review

Isopropyl alcohol vs Normal saline

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Isopropyl alcohol vs Normal saline

Rescue antiemetic · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

It is very uncertain whether isopropyl alcohol changes use of rescue antiemetics Assessed by proportion requiring rescue… compared with saline (very low certainty).

1 finding from 1 review

Isopropyl alcohol vs Normal saline

Adverse events (common reactions to aromatherapy include skin rashes, dyspnoea, headache, cardiac arrhythmias, hypotension, hypertension or dizziness) · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Any late‐onset sepsis ‐ all infants · preterm infants

It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of late‐onset sepsis compared with control (water, saline, or no intervention) (very low certainty).

1 finding from 1 review

Ear drops (any active treatment) vs ear drops (water or saline)

Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal

Ear drops (any active treatment) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with ear drops (water or saline) (low certainty).

1 finding from 1 review