Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

388 questions · 412 findings · 37 reviews · Airways

No studies found 61 · 14.8%GRADE not reported 42 · 10.2%Very low 68 · 16.5%Low 114 · 27.7%Moderate 100 · 24.3%High 27 · 6.6%

Human deoxyribonuclease vs placebo

Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) · children with primary (intrinsic) tracheomalacia

Human deoxyribonuclease showed no clear difference in clinical failure Number of children with no significant improvement… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in adults ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review