Findings

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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G allele of ENAM rs1264848 vs A allele of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of ENAM rs1264848 and dental caries susceptibility (G vs A model: OR 0.93, 95% CI 0.65-1.32); certainty not graded.

2 findings from 1 review

AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG vs AA model: OR 0.35, 95% CI 0.07-1.74) in the Age group: Children subgroup; certainty not graded.

4 findings from 1 review
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CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded.

7 findings from 1 review
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AG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG vs AA model: OR 1.07, 95% CI 0.80-1.43) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

CT + TT genotype (T-allele carriers) of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT + TT vs CC model: OR 1.14, 95% CI 0.56-2.29) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

TT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC model: OR 1.54, 95% CI 0.61-3.92) in the Age group: Children subgroup; certainty not graded.

4 findings from 1 review
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Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Marginal integrity success rate · Children with primary molars requiring proximal (Class II) restorations

After trim-and-fill adjustment the marginal integrity success rate was 0.881 (95% CI 0.832-0.916; ungraded), a negligible change.

1 finding from 1 review

GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA model: OR 1.86, 95% CI 0.96-3.62); certainty not graded.

3 findings from 1 review

No additional acid etching (self-etch adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before self-etch adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with self-etch adhesive systems (in vitro)

At the dentin margin, prior acid etching with self-etch adhesives significantly reduced microleakage (RR 2.44, 95% CI 1.38-4.34; ungraded).

2 findings from 1 review

AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG + GG vs AA model: OR 0.99, 95% CI 0.81-1.23) in the Age group: Children subgroup; certainty not graded.

4 findings from 1 review
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GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs1264848 and dental caries susceptibility (GG vs AA model: OR 0.58, 95% CI 0.19-1.82) in the Age group: Children subgroup; certainty not graded.

5 findings from 1 review
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rs1126478 genotype distribution vs Caries-free control genotype distribution

Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls

rs1126478 was inversely associated with low-level dental caries in a single study (OR 0.65, 95% CI 0.47 to 0.90; ungraded).

5 findings from 1 review
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Low birth weight (<2500 g) vs Normal birth weight (2500 g or more)

Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)

Adjusted analyses also showed no association between low birth weight and early childhood caries (adjusted OR 1.05, 95% CI 0.71 to 1.57); certainty not graded.

2 findings from 1 review

Traditional bur cavity preparation vs Er,Cr:YSGG laser cavity preparation

Incidence of microleakage · Human teeth requiring cavity preparation and restoration (in vitro)

At the dentin margin, microleakage did not differ significantly between bur and Er,Cr:YSGG laser preparation (RR 1.26, 95% CI 0.67-2.38; ungraded).

2 findings from 1 review