Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

611 questions · 621 findings · 112 reviews

No studies found 53 · 8.5%GRADE not reported 70 · 11.3%Very low 91 · 14.7%Low 216 · 34.8%Moderate 152 · 24.5%High 39 · 6.3%

Intervention not reported

BSID‐III composite cognitive scores at 18 to 22 months The Bayley‐III has 3 main sub tests: the Cognitive Scale, which includes items such as attention to familiar and unfamiliar objects, looking for a fallen object, and pretend play; the Language... · neonates born preterm with low birth weight

The intervention probably leads to higher BSID‐III composite cognitive scores at 18 to 22 months The… (moderate certainty).

1 finding from 1 review

Intervention not reported

WPPSI‐III FSIQ at 3.5 to 4 years of age Composite scores have a mean of 100 and a standard deviation of 15. Average is 90 to 109. · neonates born preterm with low birth weight

The intervention may leads to higher WPPSI‐III FSIQ at 3.5 to 4 years of age Composite scores have a mean… (low certainty).

1 finding from 1 review

Intervention not reported

Any neurodevelopmental impairment at 18 to 22 months' corrected age (in children examined) · preterm infants with low birth weight

The intervention may leads to lower any neurodevelopmental impairment at 18 to 22 months' corrected age… (low certainty).

1 finding from 1 review

Intervention not reported

Bayley‐II MDI at 18 to 24 months Bayley Scales of Infant Development, Second Edition, yields 2 single age‐standardised composite scores (range 50 to 150): a Mental Development Index (MDI), which measures cognition through sensory perception, knowl... · preterm infants with low birth weight
1 finding from 1 review

Intervention not reported

Necrotising enterocolitis (stage not reported) · preterm infants with low birth weight

The intervention probably leads to lower necrotising enterocolitis (stage not reported) (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality during initial hospital stay (all causes of mortality) · preterm infants with low birth weight

The intervention showed no clear difference in mortality during initial hospital stay (all causes of mortality) (high certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) · preterm infants with low birth weight

The intervention showed no clear difference in retinopathy of prematurity (stage ≥ 3) (high certainty).

1 finding from 1 review

Intervention not reported

Intraventricular haemorrhage (grades III and IV) · preterm infants with low birth weight

The intervention probably leads to lower intraventricular haemorrhage (grades III and IV) (moderate certainty).

1 finding from 1 review

Intervention not reported

Survivors at discharge from hospital without severe IVH, PVL, ROP · preterm infants with low birth weight

The intervention showed no clear difference in survivors at discharge from hospital without severe IVH, PVL, ROP (high certainty).

1 finding from 1 review

Intervention not reported

Use of one or more red blood cell transfusions (low and high dose of EPO) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes use of one or more red blood cell transfusions (low and high dose of… (very low certainty).

1 finding from 1 review

Intervention not reported

Necrotising Enterocolitis ≥ Bell's stage 2 during initial hospital stay · preterm infants with low birth weight

The intervention showed no clear difference in necrotising Enterocolitis ≥ Bell's stage 2 during initial hospital… (moderate certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (all stages or stage not reported) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (all stages or stage not reported) during… (very low certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (stage ≥ 3) during initial hospital stay (very low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Perinatal loss: all ‐ including miscarriages and stillbirth (Note: data not available for neonatal death)

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes perinatal loss: all ‐ including miscarriages and stillbirth (Note:… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review