Findings

What do systematic reviews say?

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

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No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

Carbamazepine vs tricyclic antidepressants (TCAs)

Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Carbamazepine vs placebo

Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Very low

Lithium vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

Lithium showed no clear difference in benzodiazepine discontinuation, end of intervention compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
RR 1.05 [0.86, 1.28]
1 study · 230 participants
Low

Intervention not reported

Physical well‐being SF‐36 Physical Component Summary Score 0 to 100, higher scores indicate higher levels of physical well‐being Immediately post‐intervention · Cancer patients with cognitive impairment due to systemic cancer treatment

1 finding from 1 review

Non‐pharmacological interventions for cognitive impairment due to systemic cancer treatment 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 95 participants
Low

Intervention not reported

Physical well‐being SF‐36 Physical Component Summary Score 0‐100, higher scores indicate higher levels of physical well‐being Two‐months post‐intervention · Cancer patients with cognitive impairment due to systemic cancer treatment

1 finding from 1 review

Non‐pharmacological interventions for cognitive impairment due to systemic cancer treatment 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 95 participants
Low

Intervention not reported

Psychological well‐being SF‐36 Mental Component Summary Score 0 to 100, higher scores indicate higher levels of physical well‐being Immediately post‐intervention · Cancer patients with cognitive impairment due to systemic cancer treatment

1 finding from 1 review

Non‐pharmacological interventions for cognitive impairment due to systemic cancer treatment 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 95 participants
Low

Intervention not reported

Psychological well‐being SF‐36 Mental Component Summary Score 0 to 100, higher scores indicate higher levels of physical well‐being Two‐months post‐intervention · Cancer patients with cognitive impairment due to systemic cancer treatment

1 finding from 1 review

Non‐pharmacological interventions for cognitive impairment due to systemic cancer treatment 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 95 participants
Low

Intervention not reported

Retention on treatment Duration of retention on treatment was not reported in these studies. The retention on treatment in this analysis is assessed by the number of withdrawals in the intervention and placebo groups The results show a trend in fa... · people with epilepsy and intellectual disability

The intervention showed no clear difference in retention on treatment Duration of retention on treatment was not… (moderate certainty).

1 finding from 1 review

Pharmacological interventions for epilepsy in people with intellectual disabilities 2015 · Cochrane Headline outcomes only
RR 1.43 [0.76, 2.69]
3 studies · 310 participants
Moderate

Intervention not reported

Seizure freedom 1 study reported the incidence of seizure frequency in the intervention and placebo group The results show a trend in favour of the AED group · people with epilepsy and intellectual disability

The intervention showed no clear difference in seizure freedom 1 study reported the incidence of seizure frequency… (low certainty).

1 finding from 1 review

Pharmacological interventions for epilepsy in people with intellectual disabilities 2015 · Cochrane Headline outcomes only
RR 2.92 [0.32, 26.77]
1 study · 73 participants
Low

Intervention not reported

fatigue (physical activity interventions) Various fatigue scales · patients with rheumatoid arthritis

1 finding from 1 review

Non‐pharmacological interventions for fatigue in rheumatoid arthritis 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 371 participants
Moderate

Intervention not reported

fatigue (psychosocial interventions) Various fatigue scales · patients with rheumatoid arthritis

1 finding from 1 review

Non‐pharmacological interventions for fatigue in rheumatoid arthritis 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1556 participants
Low

Intervention not reported

High‐dose atropine (≥ 0.5%) · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 512 participants
Moderate

Intervention not reported

Undercorrected single vision spectacles · children with progressive myopia (38 studies, 6525 participants in analyses) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Low

Intervention not reported

High‐dose atropine (≥ 0.5%) · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 428 participants
Moderate

Intervention not reported

Moderate‐dose atropine (0.1% to < 0.5%) · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 247 participants
Low

Intervention not reported

Low‐dose atropine (< 0.1%) · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 249 participants
Low

Intervention not reported

Pirenzepine · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 53 participants
Low

Intervention not reported

Multifocal soft contact lenses · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 540 participants
Low

Intervention not reported

Rigid gas‐permeable contact lenses · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 154 participants
Very low

Intervention not reported

Peripheral plus spectacle lenses · children with progressive myopia (26 studies, 4949 participants in the analysis) Interventions: optical and pharmacological Comparator:…

1 finding from 1 review

Interventions for myopia control in children: a living systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 188 participants
Very low