What do systematic reviews say?

Unfractionated heparin vs low molecular weight heparin

It is very uncertain whether unfractionated heparin changes thrombocytopenia compared with low molecular weight heparin (very low certainty).

• Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
  RR 0.57 [0.2, 1.63]
  2 studies · 124 participants
  Very low

Unfractionated heparin vs no pharmacological anticoagulation

The review found no eligible studies for this question.

• Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Citrate vs unfractionated heparin

Citrate showed no clear difference in thrombocytopenia compared with unfractionated heparin (low certainty).

• Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
  RR 0.39 [0.14, 1.03]
  3 studies · 412 participants
  Low

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

The review found no eligible studies for this question.

• Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HC (10 mg/m²/day to 15 mg/m²/day) vs PD (2.4 mg/m²/day to 3.5 mg/m²/day)

The review found no eligible studies for this question.

• Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HC (15 mg/m²/day) vs HC (25 mg/m²/day) with fludrocortisone (0.1 mg/day)

The review found no eligible studies for this question.

• Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

The review found no eligible studies for this question.

• Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Heparin plus aspirin vs aspirin

• Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 140 participants
  GRADE not reported

Anti‐EGFR therapy vs placebo or usual care

Anti‐EGFR therapy showed no clear difference in lymphopenia compared with placebo or standard of care (low certainty).

• Anti‐epidermal growth factor receptor therapy for glioblastoma in adults 2020 · Cochrane Headline outcomes only
  OR 0.97 [0.19, 4.81]
  4 studies · 1146 participants
  Low

Anti‐EGFR therapy vs placebo or usual care

Anti‐EGFR therapy showed no clear difference in neutropenia compared with placebo or standard of care (low certainty).

• Anti‐epidermal growth factor receptor therapy for glioblastoma in adults 2020 · Cochrane Headline outcomes only
  OR 1.29 [0.82, 2.03]
  4 studies · 1146 participants
  Low

Anti‐EGFR therapy vs placebo or usual care

Anti‐EGFR therapy showed no clear difference in thrombocytopenia compared with placebo or standard of care (low certainty).

• Anti‐epidermal growth factor receptor therapy for glioblastoma in adults 2020 · Cochrane Headline outcomes only
  OR 3.69 [0.51, 26.51]
  4 studies · 1146 participants
  Low

Summary of Findings Table ‐ Enoxaparin vs no enoxaparin

The review found no eligible studies for this question.

• Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

It is very uncertain whether targeted or adjustable individualized fortification changes osteopenia compared with standard non‐individualized fortification (very low certainty).

• Individualized versus standard diet fortification for growth and development in preterm infants receiving human milk 2020 · Cochrane Headline outcomes only
  RR 0.86 [0.4, 1.84]
  1 study · 60 participants
  Very low

Primary (complete) wound closure vs Secondary (partial) wound closure

Primary (complete) wound closure showed no clear difference in maximum mouth opening (mean) compared with secondary (partial) wound closure; GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  7 days
  MD -0.29 [-0.90, 0.32]
  4 studies · 274 participants
  GRADE not reported

Triangular flap vs Envelope flap

Triangular flap led to lower maximum mouth opening compared with envelope flap; GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  7 days · short triangular vs envelope
  SMD -0.67 [-1.04, -0.30]
  2 studies · 158 participants
  GRADE not reported

Piezoelectric bone removal vs Conventional rotary handpiece

Piezoelectric bone removal led to higher trismus / maximum mouth opening (mean) compared with conventional rotary handpiece; GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  7 days · piezoelectric vs conventional
  MD 2.68 [0.54, 4.81]
  4 studies · 110 participants
  GRADE not reported

Coronectomy vs Complete extraction (odontectomy)

Coronectomy showed no clear difference in maximum mouth opening (mean) compared with complete extraction (odontectomy); GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  7 days
  MD -2.94 [-8.20, 2.32]
  1 study · 30 participants
  GRADE not reported

Alteplase vs urokinase

Alteplase showed no clear difference in referral for thoracic surgery (open or thorascopic) compared with urokinase (low certainty).

• Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
  OR 0.46 [0.04, 5.24]
  1 study · 99 participants
  Low

Streptokinase vs urokinase

Streptokinase showed no clear difference in referral for thoracic surgery (open or thorascopic) compared with urokinase (low certainty).

• Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
  OR 1 [0.13, 7.72]
  1 study · 50 participants
  Low

Bispectral index vs clinical signs

• Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 1494 participants
  Low