Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Brain‐derived neurotrophic factor vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether brain‐derived neurotrophic factor changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Cerebrospinal fluid filtration vs plasma exchange

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether cerebrospinal fluid filtration changes participants with 1 or more serious adverse events compared with plasma exchange (very low certainty).

1 finding from 1 review

Eculizumab vs placebo

Participants with 1 or more serious adverse events · adults with severe Guillain‐Barré syndrome (GBS disability score > 2), within 2 weeks form onset

Eculizumab showed no clear difference in participants with 1 or more serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

CBT vs no treatment or treatment

Victim empathy: attitudes to women Measured by: Attitude Towards Women Scale (15 items; scores range from 0 to 45; higher scores indicate more egalitarian attitudes towards women) · young people (aged 10 to 18 years old) with harmful sexual behaviour
1 finding from 1 review

Nicotine replacement therapy vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Bupropion vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Procedures: donning and doffing with instructions vs No special instructions (control)

People with one or more errors · healthcare workers

It is very uncertain whether procedures: donning and doffing with instructions changes people with one or more errors compared with without instruction (very low certainty).

1 finding from 1 review

Wavefront‐guided LASIK vs wavefront‐guided PRK

Loss of 1 or more lines of BSCVA at 12 months post treatment · Adults with refractive errors

It is very uncertain whether wavefront‐guided LASIK changes proportion of eyes that had lost 1 or more lines of best… compared with wavefront‐guided PRK (very low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment:12 months ‐ Procedure PRK · Adults with refractive errors

Wavefront procedures showed no clear difference in proportion of eyes that had lost 1 or more lines of best… compared with conventional procedures (low certainty).

1 finding from 1 review