Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

436 questions · 451 findings · 96 reviews · Headline outcomes only

No studies found 31 · 6.9%GRADE not reported 17 · 3.8%Very low 149 · 33%Low 130 · 28.8%Moderate 103 · 22.8%High 21 · 4.7%

Delayed chemotherapy vs immediate chemotherapy

Nausea and vomiting · patients with asymptomatic, incurable, metastatic colorectal cancer

It is very uncertain whether delayed chemotherapy changes toxicity – nausea and vomiting compared with immediate chemotherapy (very low certainty).

1 finding from 1 review

Delayed chemotherapy vs immediate chemotherapy

Toxicity – stomatitis · patients with asymptomatic, incurable, metastatic colorectal cancer

It is very uncertain whether delayed chemotherapy changes toxicity – stomatitis compared with immediate chemotherapy (very low certainty).

1 finding from 1 review

Delayed chemotherapy vs immediate chemotherapy

Toxicity – diarrhoea · patients with asymptomatic, incurable, metastatic colorectal cancer

It is very uncertain whether delayed chemotherapy changes toxicity – diarrhoea compared with immediate chemotherapy (very low certainty).

1 finding from 1 review

TCu 220C vs Copper 7

Discontinuation due to pregnancy (750 days) · patients with Immediate insertion Post abortion

TCu 220C showed no clear difference in discontinuation due to pregnancy (750 days) compared with copper 7 (moderate certainty).

1 finding from 1 review

TCu 220C vs Copper 7

Discontinuation due to expulsion (750 days) · patients with Immediate insertion Post abortion

TCu 220C showed no clear difference in discontinuation due to expulsion (750 days) compared with copper 7 (moderate certainty).

1 finding from 1 review

TCu 220C vs Lippes Loop

Discontinuation due to perforation · patients with Immediate insertion Post abortion

TCu 220C showed no clear difference in discontinuation due to perforation (750 days) Tietze‐Potter gross… compared with lippes Loop (moderate certainty).

1 finding from 1 review

TCu 220C vs Lippes Loop

Discontinuation due to pelvic inflammation · patients with Immediate insertion Post abortion

TCu 220C showed no clear difference in discontinuation due to pelvic inflammatory disease (750 days) compared with lippes Loop (moderate certainty).

1 finding from 1 review

TCu 220C vs Lippes Loop

Discontinuation due to pregnancy (750 days) · patients with Immediate insertion Post abortion

TCu 220C probably leads to lower discontinuation rate due to pregnancy (750days) compared with lippes Loop (moderate certainty).

1 finding from 1 review

TCu 220C vs Lippes Loop

Discontinuation due to expulsion (750 days) · patients with Immediate insertion Post abortion

TCu 220C probably leads to lower discontinuation rate due to expulsion (750 days) Tietze‐Potter gross… compared with lippes Loop (moderate certainty).

1 finding from 1 review

CPR plus delayed defibrillation vs immediate defibrillation: overall analysis

Survival to hospital discharge · patients with out‐of‐hospital cardiac arrest

CPR plus delayed defibrillation showed no clear difference in survival to hospital discharge rate compared with immediate defibrillation: overall analysis (low certainty).

1 finding from 1 review

CPR plus delayed defibrillation vs immediate defibrillation: overall analysis

Neurological outcome at hospital discharge rate of good recovery · patients with out‐of‐hospital cardiac arrest

CPR plus delayed defibrillation showed no clear difference in neurological outcome at hospital discharge rate of good recovery compared with immediate defibrillation: overall analysis (low certainty).

1 finding from 1 review

CPR plus delayed defibrillation vs immediate defibrillation: overall analysis

ROSC rate · patients with out‐of‐hospital cardiac arrest

CPR plus delayed defibrillation showed no clear difference in ROSC rate compared with immediate defibrillation: overall analysis (low certainty).

1 finding from 1 review

CPR plus delayed defibrillation vs immediate defibrillation: overall analysis

Survival at 1 year rate · patients with out‐of‐hospital cardiac arrest

CPR plus delayed defibrillation showed no clear difference in survival at 1 year rate compared with immediate defibrillation: overall analysis (low certainty).

1 finding from 1 review