Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

572 questions · 579 findings · 55 reviews · Headline outcomes only

No studies found 60 · 10.4%GRADE not reported 42 · 7.3%Very low 205 · 35.4%Low 210 · 36.3%Moderate 52 · 9%High 10 · 1.7%

Intervention not reported

Bayley PDI at 12 months post‐term · Preterm infants on enteral feed

The intervention showed no clear difference in bayley PDI at 12 months post‐term (low certainty).

1 finding from 1 review

Intervention not reported

Weight at 12 months post‐term (kg) · Preterm infants on enteral feed

The intervention showed no clear difference in weight at 12 months post‐term (kg) (low certainty).

1 finding from 1 review

Intervention not reported

Length at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in length at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Intervention not reported

Head circumference at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in head circumference at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Neurodevelopmental outcomes · preterm born neonates

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

1 finding from 1 review

Intervention not reported

Invasive infection prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention probably leads to higher invasive infection prior to hospital discharge (moderate certainty).

1 finding from 1 review

High vs standard volume of unfortified human milk or term formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

1 finding from 1 review

High vs standard volume of fortified human milk or preterm formula

Extrauterine growth restriction at discharge · preterm or low birth weight infants

High showed no clear difference in extrauterine growth restriction at discharge compared with standard volume of fortified human milk or preterm formula (low certainty).

1 finding from 1 review

High vs standard volume of fortified human milk or preterm formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of fortified human milk or preterm formula (very low certainty).

1 finding from 1 review