Serious adverse events · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 28 days on/off antibiotic regimen (moderate certainty).
1 finding from 1 review
OR 0.83 [0.37, 1.86]
Studies not reported
Moderate
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · people with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
High
no estimate extracted
Studies not reported
High
Health‐related quality of life · people (of any age) with chronic suppurative otitis media or ear discharge
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · people (of any age) with chronic suppurative otitis media or ear discharge
It is very uncertain whether topical antibiotics with steroids changes ear pain (otalgia) or discomfort or local irritation compared with topical antibiotics alone (same antibiotics) (very low certainty).
1 finding from 1 review
Hearing · people (of any age) with chronic suppurative otitis media or ear discharge
2 findings from 1 review
Serious complications (including intracranial complications, extracranial complications and death) · people (of any age) with chronic suppurative otitis media or ear discharge
The review found no eligible studies for this question.
2 findings from 1 review
Suspected ototoxicity · people (of any age) with chronic suppurative otitis media or ear discharge
1 finding from 1 review
Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with chronic suppurative otitis media or ear discharge
Topical antibiotics with steroids may leads to lower resolution of ear discharge at between 1 to 2 weeks compared with topical antibiotics alone (low certainty).
2 findings from 1 review
Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with chronic suppurative otitis media or ear discharge
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Discomfort/pain · people (of any age) with chronic suppurative otitis media or ear discharge
It is very uncertain whether topical antibiotics with steroids changes ear pain or discomfort at 14 weeks compared with topical antibiotics alone (very low certainty).
1 finding from 1 review
Suspected ototoxicity: dizziness/vertigo/balance · people (of any age) with chronic suppurative otitis media or ear discharge
It is very uncertain whether topical antibiotics with steroids changes suspected ototoxicity: dizziness/vertigo/balance compared with topical antibiotics alone (very low certainty).
1 finding from 1 review
Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma
It is very uncertain whether more than 24 hours of antibiotics changes abdominal surgical site infection compared with 24 hours of antibiotics (very low certainty).
1 finding from 1 review
All‐cause mortality · people undergoing laparotomy for penetrating abdominal trauma
It is very uncertain whether more than 24 hours of antibiotics changes mortality compared with 24 hours of antibiotics (very low certainty).
1 finding from 1 review
Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma
It is very uncertain whether more than 24 hours of antibiotics changes intra‐abdominal infection compared with 24 hours of antibiotics (very low certainty).
1 finding from 1 review
Fever ‐ not measured · Women undergoing operative vaginal delivery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of maternal hospital stay (days) · Women undergoing operative vaginal delivery
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.53 [0.4, 0.69]
Studies not reported
High
Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.46 [0.31, 0.69]
Studies not reported
High
Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).
1 finding from 1 review
RR 0.11 [0.01, 2.05]
Studies not reported
Low