Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Death from all causes Range of · patients undergoing primary tumour surgery

Epidural anaesthesia in addition to general anaesthesia showed no clear difference in death from all causes Range of compared with general anaesthesia alone (low certainty).

1 finding from 1 review

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression or death from all causes Range of · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression or death from all causes Range of compared with general anaesthesia alone (very low certainty).

1 finding from 1 review

Epidural anaesthesia in addition to general anaesthesia vs general anaesthesia

Tumour progression Median · patients undergoing primary tumour surgery

It is very uncertain whether epidural anaesthesia in addition to general anaesthesia changes tumour progression Median compared with general anaesthesia alone (very low certainty).

1 finding from 1 review

Nalbuphine vs placebo

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine may leads to lower number of patients with moderate/severe pain (1 hour postoperatively) compared with placebo (low certainty).

2 findings from 1 review

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (postoperative care unit) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine vs tramadol

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (2 hours… compared with tramadol (low certainty).

3 findings from 1 review

Nalbuphine vs tramadol

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with tramadol (low certainty).

1 finding from 1 review

Nalbuphine vs pethidine

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (2 hours… compared with pethidine (low certainty).

2 findings from 1 review

Nalbuphine vs piritramid

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (24 hours… compared with piritramid (low certainty).

1 finding from 1 review

Nalbuphine vs piritramid

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with piritramid (low certainty).

1 finding from 1 review

Nalbuphine vs placebo

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine may leads to lower number of patients with the need for rescue analgesia (2 hours… compared with placebo (low certainty).

2 findings from 1 review

Nalbuphine vs placebo

Number of patients with postoperative nausea and vomiting (postoperative care unit) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting… compared with placebo (low certainty).

1 finding from 1 review

Nalbuphine vs placebo

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with placebo (low certainty).

1 finding from 1 review

Nalbuphine vs morphine

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with moderate/severe pain (1 hour postoperatively) compared with morphine (low certainty).

2 findings from 1 review

Nalbuphine vs morphine

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (12 hours… compared with morphine (low certainty).

1 finding from 1 review

Glutamine‐supplemented nutrition vs non‐supplemented nutrition

Short‐term mortality (within hospital stay or closest to one month) · critically ill patients or receiving major surgery

Glutamine‐supplemented nutrition showed no clear difference in short‐term mortality (within hospital stay or closest to one month) compared with non‐supplemented nutrition (low certainty).

1 finding from 1 review