Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Mortality at 6 months: main analysis · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality at 6 months: main analysis compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Pulmonary embolism · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

It is very uncertain whether vitamin K antagonist (VKA) prophylaxis changes pulmonary embolism compared with no prophylaxis (very low certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Symptomatic DVT · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

It is very uncertain whether vitamin K antagonist (VKA) prophylaxis changes symptomatic deep vein thrombosis compared with no prophylaxis (very low certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Major bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis probably leads to higher major bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis probably leads to higher minor bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

NSAIDs vs placebo

Adequate pain relief as reported by women · women with perineal pain in the early postpartum period

NSAID may leads to higher adequate pain relief(4 hours after administration) compared with placebo (low certainty).

2 findings from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (4 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID changes need for additional analgesia (6 hours after administration) compared with placebo (very low certainty).

1 finding from 1 review