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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

1,105 questions in 84 reviews · Metabolic and Endocrine Disorders

current versions
No studies 434 · 39.3%Ungraded 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Gastric bypass vs biliopancreatic diversion with duodenal switch (laparoscopic or open)
Comorbidities: diabetes · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 60 participantsVery low
Gastric bypass vs biliopancreatic diversion with duodenal switch (laparoscopic or open)
Mortality · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted2 studies · 107 participantsModerate
Gastric bypass vs biliopancreatic diversion with duodenal switch (laparoscopic or open)
Serious adverse events (SAEs) · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Gastric bypass vs biliopancreatic diversion with duodenal switch (laparoscopic or open)
Reoperations [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted2 studies · 107 participantsVery low
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
BMI at study end [kg/m²] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 57 participantsVery low
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
Health‐related quality of life · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
Comorbiditites: diabetes [Proportions with complete remission and partial remission] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 57 participantsVery low
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
Mortality · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 57 participantsVery low
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
Serious adverse events (SAEs) · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Surgery vs no surgery
Comobidities: diabetes Different definitions used · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted5 studies · 442 participantsModerate
Laparoscopic gastric bypass vs laparoscopic duodenojejunal bypass with sleeve gastrectomy
Reoperations [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Reduction in BMI [kg/m²] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 80 participantsVery low
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Health‐related quality of life · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Comorbidities: diabetes · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Mortality · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Serious adverse events (SAEs) · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparoscopic adjustable gastric banding vs laparoscopic isolated sleeve gastrectomy
Reoperations [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 80 participantsVery low
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
BMI at study end [kg/m²] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 30 participantsVery low
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
Health‐related quality of life · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
Comorbidities · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Surgery vs no surgery
Mortality · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted5 studies · 478 participantsModerate
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
Mortality · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 30 participantsVery low
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
Serious adverse events (SAEs) · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extractedNRNo studies
Laparaoscopic gastric imbrication vs laparoscopic sleeve gastrectomy
Reoperations [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 30 participantsVery low
Surgery vs no surgery
Serious adverse events (SAEs) [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted4 studies · 438 participantsVery low
Surgery vs no surgery
Reoperations [%] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted5 studies · 470 participantsVery low
Laparoscopic gastric bypass vs laparoscopic adjustable gastric banding
BMI at study end [kg/m²] · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted3 studies · 265 participantsModerate
Laparoscopic gastric bypass vs laparoscopic adjustable gastric banding
Health‐related quality of life Short Form Health Survey (SF‐36) · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 250 participantsVery low
Laparoscopic gastric bypass vs laparoscopic adjustable gastric banding
Comorbidities:diabetes · participants with obesity
Surgery for weight loss in adults (2014) · Cochrane
no estimate extracted1 study · 51 participantsVery low
Intervention NR
All‐cause mortality
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
RR 1.78 [0.62, 5.12]3 studies · 104 participantsLow
Intervention NR
Pressure symptoms / cosmetic complaints
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted3 studies · 370 participantsLow
Intervention NR
Nodule volume reduction ≥ 50%
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
RR 1.83 [1.32, 2.54]3 studies · 105 participantsModerate
Intervention NR
Socioeconomic effects
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
All‐cause mortality
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Thyroid cancer
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted3 studies · 97 participantsLow
Intervention NR
Pressure symptoms / cosmetic complaints
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted3 studies · 92 participantsLow
Intervention NR
Thyroid cancer
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRLow
Intervention NR
Nodule volume reduction ≥ 50%
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted1 study · 62 participantsLow
Intervention NR
Socioeconomic effects
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted1 study · 62 participantsLow
Intervention NR
All‐cause mortality
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Thyroid cancer
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted1 study · 40 participantsLow
Intervention NR
Pressure symptoms / cosmetic complaints
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted1 study · 40 participantsLow
Intervention NR
Nodule volume reduction ≥ 50%
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extracted1 study · 40 participantsLow
Intervention NR
Socioeconomic effects
Levothyroxine or minimally invasive therapies for benign thyroid nodules (2014) · Cochrane
no estimate extractedNRNo studies