Intervention not reported
Number of subjects who had one or more exacerbations over the study period in adults ( · Adults and children with asthma
The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).
1 finding from 1 review
Intervention not reported
Number of exacerbations per 52 weeks in adults ( · Adults and children with asthma
1 finding from 1 review
Intervention not reported
ICS dose at final visit in adults ( · Adults and children with asthma
1 finding from 1 review
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time ammonium bifluoride gave a 56% prevented fraction, similar to SDF (57%) (single study; ungraded).
1 finding from 1 review
Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).
2 findings from 1 review
Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)
No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).
1 finding from 1 review
Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
5 studies · 420 participants
GRADE not reported
Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Zirconia crowns showed no significant difference in crown retention versus other restorations at 6 months (RR 1.02, 95% CI 0.94 to 1.11; 3 studies; not GRADE-rated).
2 findings from 1 review
Spontaneous space closure · Children aged 5 to 15 years with a compromised first permanent molar
Early extraction of a compromised first permanent molar is followed by variable spontaneous closure of the post-extraction space (about 45.5% to 85.2% of cases); certainty was not GRADE-rated (Shekelle category III).
1 finding from 1 review
Intervention not reported
28‐Day mortality · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…
The intervention showed no clear difference in 28‐Day mortality (low certainty).
1 finding from 1 review
Intervention not reported
ICU mortality · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…
The intervention may leads to lower ICU mortality (low certainty).
1 finding from 1 review
Intervention not reported
In‐hospital mortality · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…
The intervention showed no clear difference in in‐hospital mortality (low certainty).
1 finding from 1 review
Intervention not reported
Rate of barotrauma · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…
The intervention showed no clear difference in rate of barotrauma (moderate certainty).
1 finding from 1 review
Restoration failure · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free
Aesthetic (resin-veneered) crowns showed no clear difference in restoration failure at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.
1 finding from 1 review
Occlusion · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free
Aesthetic (resin-veneered) crowns led to lower occlusion at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.
1 finding from 1 review
Proximal contact at 6 months · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free
Aesthetic (resin-veneered) crowns led to lower proximal contact at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.
1 finding from 1 review
Marginal integrity of restoration · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free
Aesthetic (resin-veneered) crowns led to lower marginal integrity at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.
1 finding from 1 review
Gingival health at 6 months · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free
Aesthetic (resin-veneered) crowns showed no clear difference in gingival health at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.
1 finding from 1 review
Any type of cancer · adult men and women who had been exposed to arsenic‐containing drinking water
1 finding from 1 review
All‐cause mortality · adult men and women who had been exposed to arsenic‐containing drinking water
1 finding from 1 review
Neurocognitive function · adult men and women who had been exposed to arsenic‐containing drinking water
1 finding from 1 review