DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Japan
The single Japanese study yielded a degenerate estimate of OR 0.00 (95% CI 0.00 to 0.00; ungraded, single study).
1 finding from 1 review
Incremental cost‐effectiveness · Children younger than 6 years (healthy except for dental caries)
In children younger than 6 years, OHPPs were associated with lower cost per DMFT/S (OR 0.07, 95% CI 0.02 to 0.32; ungraded).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published 2015 or later)
In studies published from 2015 onward, OHPPs were associated with lower DMFT (OR 0.08, 95% CI 0.01 to 0.53; ungraded).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children with dental caries
Oral-health promotion programs were associated with markedly lower odds of DMFT/S in children (OR 0.19, 95% CI 0.10 to 0.39; ungraded, very high heterogeneity I2=98.5%).
1 finding from 1 review
OR 0.19 [0.10, 0.39]
8 studies
GRADE not reported
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Finland
The single Finnish study showed lower DMFT/S with OHPP (OR 0.48, 95% CI 0.41 to 0.56; ungraded, single study).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015)
In studies published before 2015, OHPPs were associated with lower DMFT (OR 0.01, 95% CI 0.00 to 0.13; ungraded).
1 finding from 1 review
Cost‐effectiveness · Children aged 6 years and older (healthy except for dental caries)
In children aged 6 years and older, the cost-effectiveness estimate was extremely imprecise and not significant (OR 0.00, 95% CI 0.00 to 48704.6; ungraded).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 6 years and older (healthy except for dental caries)
In children aged 6 years and older, OHPPs showed no significant effect on DMFT/S (OR 0.29, 95% CI 0.08 to 1.01; ungraded).
1 finding from 1 review
Incremental cost‐effectiveness · Children with dental caries
OHPPs were associated with a lower program cost per DMFT/S in about 97 of 100 programs (OR 0.03, 95% CI 0.01 to 0.11; ungraded, very high heterogeneity I2=99%).
1 finding from 1 review
OR 0.03 [0.01, 0.11]
8 studies
GRADE not reported
DMFT/DMFS index (dental caries experience) · Children younger than 6 years (healthy except for dental caries)
In children younger than 6 years, OHPPs were associated with lower odds of DMFT/S (OR 0.14, 95% CI 0.05 to 0.39; ungraded).
1 finding from 1 review
Oral candidiasis prevalence · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette users may have a higher prevalence of oral Candida colonization than non-smokers (narrative synthesis; ungraded).
1 finding from 1 review
Narrative synthesis: e-cigarette users showed a higher prevalence of Candida spp. (e.g., C. albicans) and increased fungal species compared with non-smokers (Ralho, Camoni [32,28]); no pooled estimate reported.
2 studies
GRADE not reported
Oral microbiota composition (dysbiosis; increased periodontal/opportunistic pathogens) · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette use is associated with oral microbiota dysbiosis and increased pathogenic bacteria compared with non-smokers (narrative synthesis; ungraded).
1 finding from 1 review
Plaque index (PI) / oral hygiene · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette users tend to have a higher plaque index (more biofilm accumulation) than non-smokers (narrative synthesis of systematic reviews; ungraded).
1 finding from 1 review
Narrative synthesis: e-cigarette users exhibited a higher plaque index than non-smokers across included reviews (Shabil, Vamos, Youssef, Thiem, Figueredo, Yang [24,25,27,29,30,31]); the umbrella review reported no…
6 studies
GRADE not reported
Oral microbiota composition · Individuals assessed for oral microbiota (mainly children and adolescents)
Oral microbiota composition differs between persons with orofacial cleft and healthy controls, synthesized qualitatively across 8 studies but not meta-analyzed (ungraded).
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported
Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis
Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).
1 finding from 1 review
Severity of oral/mucosal burning pain/sensation · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.
1 finding from 1 review
Severity of oral/mucosal burning pain/sensation · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Rajendran 2006 concluded the intervention reduced pain, but pain intensity evaluations were inadequately defined and from interview data, making mean scores difficult to interpret.
1 study · 29 participants
GRADE not reported
Detection rate of oral pre-malignant and malignant lesions after referral (COE+vital rinsing vs COE alone) · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
COE with vital rinsing (toluidine blue/tolonium chloride) showed no clear difference in detection rate of oral pre-malignant and malignant lesions after… compared with conventional oral examination (COE) alone (moderate certainty).
1 finding from 1 review