Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Mortality: lung cancer · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower lung cancer‐related mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

All‐cause mortality ‐ planned time points · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower all‐cause mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Overdiagnosis Time point: ≥ 10 years from randomisation excluding CXR trials  · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in overdiagnosis Time point: ≥ 10 years from randomisation excluding… compared with no LDCT screening (low certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Any death postsurgery Time point: 6 years to 9 years from randomisation · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in any death postsurgery Time point: 6 years to 9 years from… compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Health‐related quality of life ‐ anxiety Time point: 10 months to 5 years from randomisation Measured by different scales · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in health‐related quality of life ‐ anxiety Time point: 10 months to 5… compared with no LDCT screening (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes treatment failure compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review